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KMID : 0377220010260020050
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Medical Journal of Chosun Univercity
2001 Volume.26 No. 2 p.50 ~ p.56
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Immunohistochemical and Ultrastrural Study on the Effect of Chronic Gastritis and Gastric Tumor Affected by Helicobacter pylori
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Moon Kyung-Rye
Jeong Sun-Bong
Lee Mi-Sook
Lee Mi-Ja
Suh Chae-Hong
Kim Man-Woo
Park Chan-Kuk
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Abstract
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Background and Objectives : Helicobacter pylori (H. pylori) is accepted as a principal cause of chronic gastritis and an important factor in the pathogenesis of peptic ulcer and gastric malignancy. The aim of our studies is to investigate relationships between H. pylori and gastric epithelial cells.
Materials ðods : One hundred and eighty one H. pylori positive cases of gastric biopsy specimens were studied immunohistochemically and ultrastructurally.
Results : p53 positive staining exhibited foveolar epithelial hyperplasia in 1 out of 32 cases, regeneration in 2 out of 12 cases, incomplete intestinal metaplasia in 5 out of 41 cases, complete intestinal metaplasia in 3 out of 18 cases, chronic ulcer in 1 out of 9 cases, tubular adenoma in 2 out of 14 cases and intestinal type of adenocarcinoma in 16 out of 21 cases. Ultrastructurally, H. pylori was observed to be in direct contact with the microvilli of the target cells and was demolishing the surface microvilli. The organisms were in close contact with the uncoated cell membrance. Penetration into the gastric cells by a few organisms was associated with marked cell damage and ultimately to cell disintegration.
Conclusion : Our results suggest that H. pylori plays a role in the pathogenesis of gastric cancer, leading a relatively slow, long lasting process that induces chronic active gastritis, intestinal metaplasia, dysplasia, and adenocarcinoma of intestinal type.
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KEYWORD
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Helicobacter pylori, Chronic gastritis, Gastric carcinoma, p53
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